PET Tumor Board–Case 7: A Case of a 71-year-old with PSA of 6.3, High PSA Density, and a PI-RADS 4 Lesion
The Case shows PSMA PET detected clinically significant prostate cancer missed by MRI-guided biopsy.
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Sean P. Collins, MD, PhD, is a Professor of Radiation Oncology and the Vice Chair of Faculty Affairs at the University of South Florida Morsani College of Medicine. In July 2006, Dr. Collins joined his twin brother Brian on the faculty of the Cancer Center at Georgetown University Hospital as an Attending Physician in Radiation Oncology. Dr. Collins graduated from the Medical Scientist Training Program (MSTP) at the University of Michigan in 2001. Professor Collins completed both an internship in Surgery and a residency in Radiation Oncology at Georgetown University Hospital. His area of expertise is prostate cancer, for which he treats patients using the CyberKnife®, a technology that allows for more accurate targeting of radiation therapy. Dr. Collins is a physician-scientist, and his work focuses on developing prostate cancer treatment protocols using stereotactic body radiation therapy (SBRT) to minimize the toxicity of radiation dose escalation. To date, he has treated over 2500 prostate cancer patients with SBRT and has presented his work at major meetings and published multiple papers on his experience in peer reviewed journals.
The Case shows PSMA PET detected clinically significant prostate cancer missed by MRI-guided biopsy.
Read MoreSean P. Collins, MD, PhD | Nov 2025
Dr. Sean Collins explains how PSMA PET guides intensification of salvage radiation after prostatectomy.
Read MoreA 57-year-old with favorable-intermediate risk prostate cancer illustrates PSMA PET/MRI interpretation, rib uptake pitfalls, and treatment selection.
Read MoreMultidisciplinary case review shows how PSMA PET false positives can mimic nodal disease and alter prostate cancer management.
Read MoreE. David Crawford, MD, and the panel discuss a case of a 66-year-old with elevated PSA, MRI PIRADS 5 lesion, and PSA density of 0.11.
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